The Benefits of Ginkgo Biloba Extract (Tebonin, or EGb 761) for Tinnitus Relief
Managing tinnitus can be challenging, but at Philadelphia Integrative Psychiatry, Dr. Danish and his team are dedicated to providing personalized care. One of the effective treatments we frequently explore is Ginkgo biloba extract EGb 761 (also called Tebonin), which has shown significant promise in helping individuals regain control over their lives. We understand the complexities involved in treating tinnitus, a condition that can arise from various causes such as cochlear lesions and metabolic disorders. Our commitment to research-backed approaches, even those not yet FDA-approved, reflects our dedication to holistic patient care.
The article "Ginkgo biloba extract EGb 761 versus pentoxifylline in chronic tinnitus: a randomized, double-blind clinical trial" delves into the efficacy of EGb 761 compared to pentoxifylline for chronic tinnitus treatment. This study provides valuable insights into the potential benefits and relative safety of EGb 761 for those suffering from this persistent condition.
Introduction and Background
Tinnitus is described as a perception of sound without an external source, affecting about 9.6% of the population with a 10-year incidence rate of 12.7% in the U.S. The economic burden of tinnitus is significant, with high healthcare costs. The condition has various causes, including cochlear lesions and metabolic disorders, making treatment complex. There are no FDA approved treatments for tinnitus at the time of writing of this blog.
Ginkgo Biloba Extract EGb 761 Improves Tinnitus
The study involved 197 patients with sub-chronic or chronic tinnitus, who were randomized to receive either EGb 761 or pentoxifylline over a 12-week period. Key findings include:
Symptom Reduction: Both treatments significantly improved tinnitus loudness, annoyance, anxiety, and disability scores. The Mini-TQ score decreased by -1.57 for EGb 761 and -1.94 for pentoxifylline.
Dosing: Patients received 120 mg of EGb 761 or 600 mg of pentoxifylline twice daily.
Effectiveness: The study found no significant difference in efficacy between the two treatments.
Safety Profile: EGb 761 had a lower incidence of adverse events (20 events) compared to pentoxifylline (36 events). Common side effects included gastrointestinal issues like nausea and diarrhea, with no serious adverse events reported. Patients with clotting disorders and on blood thinners should avoid using EGb 761.
Why Choose Ginkgo Biloba Extract EGb 761
The results indicate that while both treatments effectively reduce tinnitus symptoms, EGb 761 may be preferable due to its better safety profile. The lower rate of adverse events makes it a more favorable option for patients seeking relief from tinnitus without compromising their overall well-being.
EGb 761 can be purchased at various online vitamin retailers.
Contraindications
Patients who have a history of easy bleeding, previous hemorrhagic strokes, or are on blood thinners (anticoagulants) should avoid using EGb 761 because Ginkgo biloba extract has blood-thinning properties, which can increase the risk of bleeding. This effect is due to the potential interaction with anticoagulant medications, such as warfarin or aspirin, which also affect blood clotting. Combining EGb 761 with these medications can amplify their anticoagulant effects, leading to an increased risk of bleeding complications. Therefore, patients taking anticoagulants are generally advised to avoid using Ginkgo biloba extract to prevent adverse interactions.
Mechanism of Action
It’s still being elucidated, but it’s proposed that the extract's antioxidant and vasodilatory properties, along with its ability to improve microcirculation and protect cochlear cells, are believed to contribute to its effectiveness in reducing tinnitus symptom
Cognitive Benefits from Ginkgo Biloba Extract EGb 761
The research articles "Efficacy and Adverse Effects of Ginkgo Biloba for Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis" and "Treatment effects of Ginkgo biloba extract EGb 761® on the spectrum of behavioral and psychological symptoms of dementia: meta-analysis of randomized controlled trials" collectively highlight the benefits of Ginkgo biloba extract EGb761 in treating cognitive impairment and dementia. The first study, involving nine trials with 2,561 patients, demonstrates that a daily dose of 240 mg of EGb761 significantly improves cognition, activities of daily living (ADLs), and global assessments over 22-26 weeks, particularly benefiting patients with neuropsychiatric symptoms (NPS) without significant side effects. Similarly, the second article, which analyzed four placebo-controlled trials with 1,628 patients, found that the same dosage over 22 to 24 weeks effectively alleviated behavioral and psychological symptoms of dementia (BPSD) such as apathy, sleep disorders, depression, anxiety, and irritability, also reducing caregiver distress. More than 50% of patients treated with EGb761 showed improvements compared to 30-40% in the placebo group. Both studies underscore EGb761's safety and efficacy in managing cognitive decline and BPSD in dementia patients, making it a viable treatment option with a favorable safety profile.
Getting in Touch with Dr. Danish and His Team
Whether you’re struggling with tinnitus or simply want a comprehensive mental health evaluation, our team is here to help. At Philadelphia Integrative Psychiatry, we offer specialized diagnostic tools and therapies not widely available elsewhere. Our integrative approach ensures that each patient receives personalized care tailored to their unique needs.
For More on This Topic and Related Subjects, Check Out These Blogs by Dr. Danish:
https://phillyintegrative.com/blog/dr-danishs-guide-to-tourette-syndrome-and-tic-disorders
https://phillyintegrative.com/blog/functional-psychiatry-a-new-perspective-on-mood-disorders-and-brain-health
Meta Description: Discover the benefits of Ginkgo biloba extract EGb 761 for tinnitus relief at Philadelphia Integrative Psychiatry. Learn about its efficacy and safety profile.
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