Managing Trichotillomania: Insights and Treatment Options

Dr. Danish and his team at Philadelphia Integrative Psychiatry frequently encounter patients struggling with trichotillomania (TTM), a condition characterized by a compulsive urge to pull out one's hair. This disorder can significantly impact an individual's quality of life, leading to noticeable hair loss and emotional distress. By understanding the underlying motivations and employing a holistic treatment approach, Dr. Danish aims to provide comprehensive care that addresses both the physical and psychological aspects of TTM.

TTM, also known as hair-pulling disorder, is a complex condition that often requires a multifaceted treatment plan. At Philadelphia Integrative Psychiatry, we combine evidence-based therapies with lifestyle adjustments to help patients manage their symptoms effectively. This blog will delve into the motivations behind hair-pulling, the relationship between TTM and OCD, and the various therapeutic and medication options available.

What is Trichotillomania?

TTM is a disorder characterized by a compulsive desire to pull out one's hair, which can lead to noticeable hair loss and significant distress. It often overlaps with skin-picking behaviors and can affect individuals of all ages. The condition is more than just a bad habit; it is a mental health disorder that requires professional intervention.

Subtypes of Trichotillomania

The article identifies three subtypes of TTM:

  1. Sensory-Sensitive Pullers: These individuals have heightened sensitivity to sensory stimuli and experience infrequent, low-intensity urges to pull hair.

  2. Low-Awareness Pullers: The most common subtype, comprising 54.2% of cases, characterized by automatic pulling behavior often triggered by emotional factors.

  3. Impulsive/Perfectionist Pullers: These individuals pull hair to control unpleasant feelings and exhibit higher levels of impulsivity and perfectionism.

Comorbid Conditions

TTM often coexists with other mental health conditions, including:

  • Anxiety Disorders: High rates of generalized and social anxiety.

  • Depression: Contributes to the overall burden and impacts self-esteem.

  • Obsessive-Compulsive Disorder (OCD): Shares similarities in repetitive behaviors.

  • Skin Picking Disorder: Often co-occurs and requires integrated treatment.

  • Attention-Deficit Hyperactivity Disorder (ADHD): 15.3% of adults with TTM also have ADHD.

  • Substance Use Disorders: Substance abuse may serve as a coping mechanism.

  • Suicidal Ideation: Higher rates compared to the general population.

Is Trichotillomania a Form of OCD?

While TTM shares some similarities with Obsessive-Compulsive Disorder (OCD), it is not the same condition. There is a higher prevalence of OCD among those with TTM, but many individuals with TTM do not have OCD. The two conditions are distinct and require different treatment approaches.

Therapeutic Approaches 

  • Habit Reversal Training (HRT): This type of therapy is effective for treating TTM, as well as other repetitive behaviors like skin-picking and nail-biting. HRT involves increasing awareness of the behavior and developing alternative responses to the urge to pull hair. This therapy is often available at anxiety treatment centers that also treat OCD, although OCD itself is typically treated with exposure and response prevention (ERP).

  • Dialectical Behavior Therapy (DBT): Effective in improving symptom severity and emotional regulation.

  • Acceptance and Commitment Therapy (ACT): Encourages acceptance of emotional responses and increases cognitive flexibility.

  • Exposure and Ritual Prevention Therapy: Involves hierarchical exposure to triggers and management of emotional dysregulation.

  • Comprehensive Behavioral Model Therapy: Addresses sensory, cognitive, affective, motor, and place factors.

Medications for Trichotillomania

Several medications have shown promise in treating TTM. To date, results across studies are mixed, and no medications are FDA approved for TTM. 

  • Olanzapine (Zyprexa): This atypical antipsychotic has been effective in reducing TTM symptoms in a double-blind study. The average dose in the study was 10mg, with doses ranging from 2.5mg to 15mg per day. However, it has a high potential for side effects, including significant weight gain.

  • Dronabinol: A cannabinoid agonist, dronabinol showed a reduction in TTM symptoms in an open-label trial at a mean dose of 11.6 mg/day. While the research supporting dronabinol is not as robust as that for NAC and olanzapine, it remains a promising option.

  • N-acetylcysteine (NAC): NAC has demonstrated benefits in double-blind, placebo-controlled studies. It is an antioxidant that helps regulate glutamate levels in the brain, which may reduce the urge to pull hair. (Read Dr. Danish’s blog on dosing, efficacy, and potential side effects of NAC). 

  • SSRI Antidepressants (Lexapro & Zoloft for instance): While these are considered first line treatment for OCD, their results in treating TTM are less robust. There are some studies showing efficacy with higher doses of various SSRIs, including Lexapro (escitalopram) and Zoloft (sertraline). Some studies, such as one looking at Prozac (fluoxetine), were negative. 

  • Clomipramine: A tricyclic antidepressant, with unique side effects (read Dr. Danish’s blog here on this TCA class of antidepressants) and high efficacy in OCD, has shown some promise in treating TTM. 

  • Opiate Receptor Blockers: Naltrexone has shown potential benefits, though more robust studies are needed. Read these blogs for more information on naltrexone dosed at 50mg and the evolving research behind low-dose-naltrexone, or LDN

  • Botulinum Toxin: There is a case report of a patient with severe and chronic TTM of the hair on their scalp benefiting from botox treatments to the affected areas. 

Getting in Touch with Dr. Danish and His Team

At Philadelphia Integrative Psychiatry, we specialize in diagnosing and treating TTM. Our holistic and integrative approach ensures that we consider all aspects of our patients' well-being in developing personalized treatment plans. If you or a loved one are seeking support for TTM or similar conditions, please text or call 610-999-6414 to learn how we can help.

For more on this topic and related subjects, please look at these blogs:

  1. Discover how we treat OCD with a comprehensive approach at Philadelphia Integrative Psychiatry.

  2. Unveil the power of Cognitive Behavioral Therapy in managing and overcoming OCD.

  3. Explore innovative OCD treatments available at Philadelphia Integrative Psychiatry.

  4. Many patients with OCD will require SSRIs or SNRIs be dosed at the high end of the dose range, and, in some cases, even higher than what is listed by the manufacturer. 

  5. Follow our guide to seeking OCD treatment for a structured path to recovery.

  6. Understand inflammation's role in tic disorders and OCD through our latest blog.

  7. Learn about the nuances of social and relationship OCD and effective ways to manage it.

  8. Consider Pregabalin as an augmentation strategy for treatment-resistant OCD.

  9. Discover the benefits of N-acetylcysteine (NAC) as a supplement for OCD.

  10. Learn about Inositol for OCD and its potential benefits in our latest post.

  11. Understand the application of Memantine in treating OCD symptoms effectively.

Sources: 

  1. https://pubmed.ncbi.nlm.nih.gov/34582562/

  2. https://pubmed.ncbi.nlm.nih.gov/37940058/

  3. https://pubmed.ncbi.nlm.nih.gov/37731870/

  4. https://pubmed.ncbi.nlm.nih.gov/35551067/

  5. https://pubmed.ncbi.nlm.nih.gov/35764619/

  6. https://pubmed.ncbi.nlm.nih.gov/36731940/



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