Pitolisant (Wakix) and Histamine-3 Receptor Antagonists
Introduction:
At Philadelphia Integrative Psychiatry, we are committed to staying informed about the latest treatments for conditions like daytime sleepiness and narcolepsy, which affect many of our patients. Our approach combines holistic care, treating patients as whole individuals, with a focus on research-driven solutions to enhance their overall well-being.
In the study "Pitolisant and Other Histamine-3 Receptor Antagonists An Update on Therapeutic Potentials and Clinical Prospects" by Harwell and Fasinu, the authors explore the advancements in histamine-3 receptor antagonists, particularly Pitolisant (Brand name Wakix). This research provides crucial insights into the drug's effectiveness and broad potential applications in treating various neurological conditions.
Highlights of the Study:
Pitolisant acts on histamine-3 receptors in the central nervous system, playing a key role in arousal and cognition enhancement.
It has emerged as a new class of drugs for treating narcolepsy, with or without cataplexy, and is well-tolerated at recommended doses.
The study found Pitolisant effective in enhancing wakefulness in narcolepsy patients and potentially beneficial in treating Parkinson's disease, epilepsy, ADHD, Alzheimer's disease and dementia.
Pitolisant shows a lower abuse potential compared to other narcolepsy medications.
The study, conducted in June 2020, included 26 publications, indicating that histamine-3 receptor antagonists are relatively new with limited clinical utility to date.
Clinical Implications:
Pitolisant is approved for treating excessive daytime sleepiness in narcolepsy patients in the US and Europe.
It is available as an oral tablet, with doses ranging from 17.8 mg to 35.6 mg daily.
Potential side effects include insomnia, nausea, anxiety and QT interval prolongation.
Further research is needed to explore Pitolisant's efficacy in other central nervous system disorders.
Conclusion:
Philadelphia Integrative Psychiatry is dedicated to providing innovative and effective treatments for chronic fatigue. We ensure our patients are informed about the latest advancements in medications like Pitolisant and their potential impact on their health.
To learn more about how we can support your mental health and overall well-being, visit www.phillyintegrative.com or call 610-999-6414 for a consultation. We offer comprehensive and integrative care, uniting families and healthcare providers for the betterment of our patients.
