Tebonin (EGb 761): A Ginkgo Extract for Tardive Dyskinesia and Other Mental Health Benefits

Written By Dr. David Danish

Introduction:

Tebonin, known generically as EGb 761, is a standardized extract of Ginkgo biloba that has been extensively studied since its introduction in 1965 for its potential benefits in treating various mental health conditions, including Tardive Dyskinesia (TD). Originally utilized primarily for managing dementia and age-related cognitive decline, Tebonin supports peripheral blood circulation to areas such as the legs, feet, and hands, while also maintaining capillary health and cognitive functions. This overview, grounded in reputable journal articles, provides detailed insights into its use, effectiveness, and dosing guidelines, highlighting its use in treating tardive dyskinesia. 

Efficacy in Treating Tardive Dyskinesia:

The neuroprotective and antioxidant properties of Tebonin have prompted research into its potential for treating tardive dyskinesia. It was evaluated in three randomized controlled trials involving 300 patients, where it demonstrated significant effectiveness with a very small p-value of four zeros. By comparison, FDA-approved medications for the same condition, such as Ingrezza and Austedo, were tested in about 400 patients each and achieved p-values with only two zeros, indicating a higher statistical significance in Tebonin's results. This evidence underscores Tebonin's potential as a valuable treatment option in the field of mental health.

  • Clinical studies have shown that Tebonin can be effective in treating symptoms of TD, particularly in patients with schizophrenia. In a controlled trial, approximately 51.3% of patients treated with EGb 761 showed a significant reduction in TD symptoms compared to 5.1% in the placebo group.

Dosing Guidelines:

For the treatment of TD, Tebonin is typically administered at a dose of 240 mg per day. This dosage has been used in clinical trials and has been found to be effective in reducing symptoms.

Best Time to Take Tebonin:

Tebonin should be taken daily with a meal to enhance absorption and reduce the risk of gastrointestinal discomfort. It is generally recommended to take the dose in the morning, although specific timing can be adjusted based on individual tolerance and the advice of a healthcare provider.

I recommend this particular brand of Tebonin, which is manufactured in Germany and approved as a prescription medication by German regulators (though it is available over-the-counter in the United States). You can find it here: Tebonin Egb 761 - 30 tablets.

Potential Side Effects:

While Tebonin is considered safe for most people, some may experience minor side effects such as stomach upset, headache, dizziness, and allergic skin reactions. There is also a concern that it might increase the risk of bruising and bleeding or cause arrhythmia in susceptible individuals.

Potential Contraindications:

Patients taking anticoagulant or antiplatelet medications should use Tebonin with caution due to the increased risk of bleeding. Additionally, those with a history of seizures or taking other medications that lower the seizure threshold should consult their healthcare provider before starting Tebonin.

Other Mental Health Benefits:

Research supports the use of Tebonin for several other mental health conditions:

  • Dementia and Alzheimer's Disease: Daily intake of 240 mg may slightly improve symptoms and cognitive function.

  • Anxiety: Specific extracts like EGb 761 can reduce anxiety symptoms when taken for at least 4 weeks.

  • Schizophrenia: Adjunctive treatment with Tebonin can reduce certain symptoms of schizophrenia and may alleviate side effects associated with antipsychotic medications.

Sources:

Dr. David Danish
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