When folate can’t get into the brain , it can cause major problems throughout the body.

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It’s more than a folate deficiency.

It’s a disconnect.

But we can restore the flow of folate into the brain with:

Leucovorin.

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Leucovorin gives the brain the folate it needs when the usual pathway is blocked.

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Leucovorin can support many journeys.

What are you navigating right now:__

$$Autism Spectrum Disorder$$4$$active

Autism Spectrum Disorder

For some children with autism, it’s not a lack of language

—it’s a blocked pathway in the brain.

Many autistic children—especially those who are non-speaking—have something most parents and providers don’t test for: Folate receptor autoantibodies (FRAA)

These antibodies block folate from crossing the blood-brain barrier. And without enough folate in the brain, essential functions begin to break down.

The result:

  • Low brain folate levels (Cerebral Folate Deficiency)

  • Delays in speech, motor skills, and social development

  • Neurological symptoms that don’t respond well to therapy or medication alone

Leucovorin: A New Path In ✨

Leucovorin is a prescription form of folate that takes a different route into the brain—bypassing the blockage that regular folate can’t get through.

Once it’s in, it helps:

  • Restore the folate levels the brain needs

  • Support language, behavior, and emotional regulation

  • Boost communication between neurons and reduce inflammation

What Parents Are Seeing

In clinical studies and real-world families, Leucovorin has led to powerful changes—especially in non-speaking children:

  • New words and vocalizations

  • Greater understanding of language

  • More eye contact, connection, and calm

  • A child who starts to feel more present

These aren’t miracle claims. They’re the result of giving the brain what it’s been missing.

Could This Be the Missing Piece for Your Child?

We’re here to help you find out—quickly, clearly, and with support.

🧪 Testing is simple.

💊 Treatment is accessible.

👨‍⚕️ Dr. Danish and his team will guide you every step of the way.

  • Please note: before we begin treatment, your child first must meet one of the following:

    • A diagnosis of autism

    • A positive Folate Receptor Alpha Antibody (FRAA) test

    • A documented speech delay

    No diagnosis? No problem—we can assess and diagnose virtually.

  • To help us get a full picture of your child’s needs, our intake form asks for a few important items:

    • Photo Identification (for the parent or guardian)

    • A short video of your child that shows their behavior, communication style, or any areas of concern you're seeking support for

    • Any existing documentation—such as a diagnosis, evaluation reports, or past testing results

    • (Optional) A note from your doctor stating that it’s safe for your child to try Leucovorin, if available

    This information helps our team create the most thoughtful and effective treatment plan for your child.

    • A quick conversation to confirm eligibility, answer questions, and explain next steps.

  • Dr. Danish will design a custom dosage schedule based on your child’s age, weight, and symptoms. You’ll get a copy of the treatment plan—and if you'd like to talk through it, we can schedule a virtual appointment to review everything together.

  • We’ll send the 12 week Leucovorin prescription to the pharmacy of your choice. Begin giving your child Leucovorin as prescribed.

  • At the end of 12 weeks, we’ll retest for FRAA and evaluate your child’s response to the treatment.

Take the first step toward a Leucovorin treatment plan designed specifically for your child’s needs.

Make sure you have the following ready before starting the form:

  • • Photo Identification

  • • A short video of your child that shows their behavior, communication style, or any areas of concern you're seeking support for

  • • Any existing documentation—such as a diagnosis, evaluation reports, or past testing results

  • • Optional: a note from your doctor stating that it’s safe for your child to try Leucovorin, if available

When you're ready, click below to get started👇

$$Infertility & Recurrent Pregnancy Loss$$5

Infertility & Recurrent Pregnancy Loss

In some pregnancies, folate is there but —

—a blocked pathway keeps it from reaching the baby.

Some women have folate receptor autoantibodies (FRAs)—proteins made by the immune system that block the folate receptor-α, a main pathway for getting folate (vitamin B9) into cells, the placenta, and the developing baby.

Even if your blood folate levels are normal and you take prenatal vitamins, this block can mean your reproductive system and fetus still aren’t getting enough folate. That shortage can raise the risk of pregnancy complications.

Folate is critical for DNA synthesis, egg quality, embryo development, and neural tube formation.

  • This is a transport problem, not an intake problem—FRAs stop folate from reaching where it’s needed, even with a healthy diet.

  • Risks of folate transport problems include neural tube defects, miscarriage, preterm birth, and sometimes fertility struggles.

  • It can run in families—close relatives may also carry FRAs.

Leucovorin: A New Path In ✨

Leucovorin (folinic acid) is an active form of folate that can bypass the blocked receptor and use alternate “side doors” into your cells and placenta.

In women with FRAs, high-dose folinic acid can restore folate delivery before and during pregnancy—helping protect fertility, reduce miscarriage risk, and support the baby’s brain and nervous system.

What Patients Are Seeing

  • Feeling more confident about preconception health.

  • Fewer early pregnancy losses.

  • Peace of mind knowing folate delivery is optimized.

These aren’t miracle claims. They’re the result of giving the body what it’s been missing.

Bottom line: If FRAs are blocking folate transport, leucovorin is one of the most direct, targeted ways to fix the problem.

Could This Be the Missing Piece for Your Family?

We’re here to help you find out—quickly, clearly, and with support.

🧪 Testing is simple.

💊 Treatment is accessible.

👨‍⚕️ Dr. Danish and his team will guide you every step of the way.

  • We recommend FRAT testing in all fertility/pregnancy cases.

    • FRAT = Folate Receptor Antibody Test (measures blocking & binding FRAs).

    • Stop high-dose folate (folinic acid or L-methylfolate) 48 hours before the blood draw.

    • Receive results in 3–4 weeks

  • To help us get a full picture of your needs, our intake form asks for a few important items:

    • Your most recent weight (for dosing)

    • A complete medication/supplement list, including folate types and last dose

    • Your fertility/pregnancy history (losses, NTD cases, family history)

    • FRAT details — order info or results if already done

    This information helps our team create the most thoughtful and effective treatment plan for you.

  • A quick chat to confirm eligibility, answer your questions, and outline next steps—including diet changes (like cutting back on dairy if positive) and planning conception timing.

  • Dr. Danish will design a custom dosage schedule based on your needs. You’ll get a copy of the treatment plan—and if you'd like to talk through it, we can schedule a virtual appointment to review everything together.

  • We’ll send the Leucovorin prescription to the pharmacy of your choice. Begin taking as prescribed.

  • We will follow up by monitoring from preconception through early pregnancy, and may retest FRAT if symptoms persist despite a negative result.

Take the first step toward a Leucovorin treatment plan designed specifically for your pregnancy

Make sure you have the following ready before starting the form:

  • • Your most recent weight (for dosing)

  • • A complete medication/supplement list, including folate types and last dose

  • • Your fertility/pregnancy history (losses, NTD cases, family history)

  • • FRAT details — order info or results if already done

When you're ready, click below to get started👇

$$Treatment-Resistant Depression$$6

Treatment-Resistant Depression

When pathways to the brain are blocked

—depression often doesn’t respond to medication or therapy.

This can happen because the brain isn’t getting the nutrients it needs to work properly. Folate (vitamin B9) is one of the most important, since it helps the brain make mood-regulating chemicals like serotonin and dopamine. But if the “doorway” that lets folate into the brain is blocked, the brain can run low on it—even when blood levels look normal. This is called cerebral folate deficiency (CFD), and it can make depression much harder to treat.

Why is it a problem?

  • Folate is crucial for making mood-regulating brain chemicals.

  • If the brain doesn’t get enough folate, antidepressants may not work as well.

  • Blockages in folate transport can be caused by antibodies against the folate receptor (detected by the Folate Receptor Antibody Test, or FRAT).

  • Regular folic acid or even L-methylfolate may not work if the folate receptor is blocked.

  • Without treatment, depression symptoms may persist, along with fatigue, brain fog, or cognitive slowdown.

Leucovorin: A New Path In ✨

Leucovorin (folinic acid) is an active form of folate that can bypass the blocked receptor and enter the brain using an alternate route. This helps restore healthy folate levels inside the brain, allowing it to make the neurotransmitters needed for mood regulation. Think of it as using a side door when the front door is locked.

What Patients Are Seeing

Some people with treatment-resistant depression notice improved mood, clearer thinking, and better energy within weeks to months of starting leucovorin—especially if they tested positive for folate receptor antibodies.

These aren’t miracle claims. They’re the result of giving the brain what it’s been missing.

Could This Be the Missing Piece for You?

We’re here to help you find out—quickly, clearly, and with support.

🧪 Testing is simple.

💊 Treatment is accessible.

👨‍⚕️ Dr. Danish and his team will guide you every step of the way.

  • Please note: In most cases, we recommend checking for folate receptor antibodies first. This helps confirm if folate transport is blocked. We can order this test for you as part of our intake process.

  • To help us get a full picture of your needs, our secure intake form asks about your health history and current medications.

    This information helps our team create the most thoughtful and effective treatment plan for you.

    • A quick conversation to confirm eligibility, answer questions, and explain next steps. We’ll review your test results and intake to decide on the right starting dose.

  • Dr. Danish will design a custom dosage schedule based on your weight and symptoms. You’ll get a copy of the treatment plan—and if you'd like to talk through it, we can schedule a virtual appointment to review everything together.

  • We’ll send the 12 week Leucovorin prescription to the pharmacy of your choice. Begin taking Leucovorin as prescribed.

  • At the end of 12 weeks, we’ll retest for FRAA and evaluate your response to the treatment.

Take the first step toward a Leucovorin treatment plan designed specifically to treat your depression.

Make sure you have the following ready before starting the form:

  • • A list of the medications you are currently taking

  • • FRAT details — order info or results if already done

When you're ready, click below to get started👇

$$PANS/PANDAS$$7

PANS/PANDAS

Sometimes the real problem isn’t behavior

—it’s a blocked pathway in the brain.

In children with PANS or PANDAS, antibodies can block folate (vitamin B9) from entering the brain. Even if blood tests look normal, the brain can still be “folate-starved”—a problem called cerebral folate deficiency.

This folate block can make symptoms like OCD, tics, anxiety, brain fog, and mood swings even worse.

Why it matters:

  • Folate is essential for brain function, but folate receptor autoantibodies (FRAA) block its entry.

  • FRAA are present in ~64% of PANS/PANDAS patients, compared to ~5–10% of the general population.

  • Low brain folate can affect neurotransmitters, mood, cognition, and energy.

  • Similar folate issues are well-documented in autism, where leucovorin therapy has shown benefits.

Leucovorin: A New Path In ✨

Leucovorin (folinic acid) is a “ready-to-use” form of folate that can enter the brain through an alternate transport pathway not blocked by these antibodies.

Think of it as using a “side door” to deliver folate to brain cells, bypassing the antibody “front door lock.”

Once brain folate is restored, symptoms related to folate deficiency may improve.

What Families Are Seeing

  • Calmer mood, less anxiety

  • Fewer or milder tics

  • OCD symptoms less intense

  • Better focus, memory, and organization

  • More energy and improved mood stability

These aren’t miracle claims. They’re the result of giving the brain what it’s been missing.

Could This Be the Missing Piece for Your Child?

We’re here to help you find out—quickly, clearly, and with support.

🧪 Testing is simple.

💊 Treatment is accessible.

👨‍⚕️ Dr. Danish and his team will guide you every step of the way.

  • Please note: before we begin treatment, your child first must have:

    • FRAT blood test (Folate Receptor Antibody Test) is recommended for all suspected cases — it confirms the folate blockade and guides dosing. We can ship the testing kit to your home and provide instructions for blood draw.

    • Baseline labs: Vitamin B12, folate, homocysteine, ± methylmalonic acid (MMA) to ensure nutritional balance before starting.

    • Medical review: Screen for any rare contraindications (like certain drug interactions).

    We can help you with all of this ☺️

  • To help us get a full picture of your child’s needs, our secure intake form asks for health history, medications, recent lab results, and where we should ship your FRAT test kit.

    This information helps our team create the most thoughtful and effective treatment plan for your child.

    • A quick conversation to review your child’s history, symptoms, lab results, and explain next steps.

  • Dr. Danish will design a custom dosage schedule based on your child’s age, weight, and symptoms. You’ll get a copy of the treatment plan—and if you'd like to talk through it, we can schedule a virtual appointment to review everything together.

  • We’ll send the 12 week Leucovorin prescription to the pharmacy of your choice. Begin giving your child Leucovorin as prescribed.

  • We’ll schedule follow-up check-ins, repeat labs at 4–6 months, and then yearly.

Take the first step toward a Leucovorin treatment plan designed specifically for your child’s needs.

Make sure you have the following ready before starting the form:

  • • Track your child’s symptoms for at least 1–2 weeks so you can clearly measure changes after starting treatment.

When you're ready, click below to get started👇