A Breakthrough Treatment Option: Leucovorin
for Autism, PANS/PANDAS, and Depression
Leucovorin (folinic acid) is a breakthrough prescription treatment that helps restore folate to the brain when usual pathways are blocked. Philadelphia Integrative Psychiatry is making Leucovorin treatment accessible nationwide.
- Licensed in 40+ states
- Led by double board-certified psychiatrist Dr. David Danish.
We’ve seen how Leucovorin can transform lives.
Why Leucovorin?
What looks like symptoms may actually be a blocked brain pathway.
Delayed speech, tics, mood instability, or even treatment-resistant depression are linked to Folate receptor autoantibodies (FRAA).
These antibodies block folate from reaching the brain, creating a hidden deficiency — even when blood tests appear normal.
When folate can’t reach the brain, Leucovorin helps open the door.
Leucovorin (folinic acid) is a prescription-grade form of folate that bypasses this blockade and restores folate directly to the brain. Unlike over-the-counter folate, Leucovorin is used in targeted, research-backed doses.
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What Families and Research Are Showing:
New words
Stronger language
More social connection
Improved focus, memory, and organization
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What Families and Research Are Showing:
Calmer moods
Reduced tics
Fewer symptoms of OCD and anxiety
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What families and research are saying about Leucovorin:
Leucovorin therapy has been studied most extensively in autism, with multiple randomized controlled trials showing meaningful improvements. Early clinical evidence and case reports suggest benefits in PANS/PANDAS and mood disorders as well.
💬 New words, stronger language, and more social connection in autism
😌 Calmer moods and reduced tics in PANS/PANDAS
🎯 Improved focus, memory, and organization
⚡ Better energy and mood regulation in depression
These aren’t miracle claims — they are outcomes supported by growing scientific evidence on folinic acid.
Explore Leucovorin by Condition:
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Leucovorin for Autism Spectrum Disorder
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Leucovorin for PANS/PANDAS
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Leucovorin for Treatment-Resistant Depression
What Is the Folate Receptor Antibody Test (FRAT)?
The Folate Receptor Antibody Test (FRAT) is a specialized blood test that checks for antibodies that block folate from reaching the brain.
For Autism:
PANS/PANDAS, and Depression: FRAT testing helps confirm if folate transport problems are driving symptoms.
For Infertility:
FRAT testing can be ordered as a standalone service, since folate receptor antibodies are linked to pregnancy complications and miscarriage.
To get started with FRAT testing or the Leucovorin treatment:
Who is Leucovorin for?
You or your child may be eligible if you have:
🗣️ An autism diagnosis with speech or social delays
🧠 PANS or PANDAS with OCD, tics, or mood symptoms
🌧️ Treatment-resistant depression not improving with standard therapies
🧪 A positive FRAT test confirming folate receptor autoantibodies
PLUS ✅ Live in one of our licensed-to-treat states
How Our Leucovorin Treatment Process Works:
1. Fill out our intake form
This form gives us a chance to understand your story and what you need most. It also helps us confirm that you’re in our service area so we can provide Leucovorin treatment to you.
2. Connect with our team
Meet with Dr. Danish or a licensed team member for a 25-minute intake to see if Leucovorin, FRAT testing, or both are the right fit.
Note: This intake is not a full autism evaluation or a comprehensive psychiatric medication review.
3. Choose your path
After our call, you’ll either begin a 12-week Leucovorin treatment plan, move forward with FRAT testing at a local lab, or take both steps together if that’s the best fit.
4. Stay Connected
Reach out anytime through our portal, and schedule follow-ups only when you need them.
5. Nationwide Access
FRAT testing is available in all 50 states, and Leucovorin prescriptions are offered in 40+ states—so care can reach you wherever you are.
It all starts with sharing your story through our intake form and scheduling a call with our team.
Leucovorin Treatment FAQ
Get answers to the top questions from our patients. From what to expect with Leucovorin treatment to what it costs.
Philadelphia Integrative Psychiatry is a licensed clinical practice offering innovative, research-informed psychiatric treatments.
National Leucovorin treatment is led by Dr. David Danish, a double board-certified child, teen, and adult psychiatrist with over 20+ years of experience. Dr. Danish and the Philadelphia Integrative Psychiatry team are committed to making Leucovorin treatment safe, accessible, and supported every step of the way.