Vitamin D3: Its Role in Mental and Medical Health Disorders
Introduction
Vitamin D3 is important in your body for a variety of reasons. Its most vital role is helping in calcium absorption. But it serves many other functions as well: It helps with immunity, mood regulation, and even aids in healthy weight regulation.
The kind of Vitamin D we normally get in our diet requires sunlight for activation to its active form, so many people have low or insufficient vitamin D in northern climates where there isn't as much sunlight, especially in the fall/winter/early spring months. The type of Vitamin D taken as a supplement (called Vitamin D3) is already in its active form, so it doesn't need sunlight to activate it.
What Percentage of Patients Benefit from Vitamin D3 supplementation?
Research indicates positive responses to Vitamin D3 supplementation for various mental health conditions, but only in patients who are insufficient (25 to 30 ng/ml) or deficient (serum levels below 25 ng/ml).
Dosing Recommendations
Dosing depends on the extent of the Vitamin D3 deficiency. For patients with serum levels of:
20 to 30 ng/ml take 2000 IU per day ongoing
10 to 20 ng/ml take 5000 IU per day x30 days and then recheck
< 10 ng/ml consider 10000 IU per day x30 days and then recheck
Optimal Timing for Supplementation
Vitamin D3 is best taken with meals to enhance its absorption, particularly with foods high in fat, as Vitamin D is fat-soluble. Morning or noon is preferable to avoid potential interference with sleep, as some evidence suggests that taking Vitamin D late in the day might disrupt nighttime rest.
Potential Side Effects
While Vitamin D3 is generally safe, excessive intake can lead to adverse effects such as hypercalcemia, characterized by nausea, weakness, and frequent urination. It is crucial to adhere to recommended dosages and consult healthcare providers for personalized advice.
If you are prone to kidney stones, consult with your PCP or nephrologist before starting Vitamin D3 supplementation.
Potential Contraindications
Individuals with conditions such as hyperparathyroidism, sarcoidosis, or kidney disease should exercise caution with Vitamin D supplementation. These conditions can affect Vitamin D metabolism, potentially leading to complications.
If you are prone to kidney stones, consult with your PCP or nephrologist before starting Vitamin D3 supplementation.
FDA Approval Information
Vitamin D3 supplements are regulated by the FDA as dietary supplements, which means they are not approved by the FDA for the treatment of any specific disease. They are, however, recognized as essential for bone health and overall well-being.
Off-Label Benefits Supported by Research
Beyond its role in bone health, Vitamin D3 has been studied for its potential benefits in reducing the risk of certain cancers, improving heart health, and aiding in the management of diabetes. Some studies also suggest a role in reducing inflammation and supporting immune health, although these benefits are considered off-label uses.
Where to purchase?
NatureMade makes 2000, 5000, and 10000 IU doses.
Sources:
1. Scientific American: https://www.scientificamerican.com/article/vitamin-d-supplements-probably-wont-prevent-mental-illness-after-all/
2. NCBI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584834/
