Could Leucovorin Help Calm OCD, Tics, and Anxiety in PANS/PANDAS?

Leucovorin (folinic acid) is a breakthrough prescription treatment that helps restore folate to the brain when usual pathways are blocked. Philadelphia Integrative Psychiatry is making Leucovorin treatment accessible nationwide.

  • Licensed in 40+ states
  • Led by double board-certified psychiatrist Dr. David Danish.

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Why Leucovorin?

What looks like symptoms may actually be a blocked brain pathway.

Many children with PANS or PANDAS have folate receptor autoantibodies (FRAs) that block folate from entering the brain.

These antibodies block folate from reaching the brain, creating a hidden deficiency — even when blood tests appear normal. This hidden deficiency can fuel symptoms like:

  • OCD and intrusive thoughts

  • Tics (motor and vocal)

  • Anxiety and emotional lability

  • Brain fog, memory issues, and poor focus

  • Mood swings and fatigue

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When folate can’t reach the brain, Leucovorin helps open the door.

Leucovorin (folinic acid) is a prescription-grade form of folate that bypasses this blockade by using an alternate “side door” into the brain, restoring healthy folate levels where it matters most. This makes Leucovorin a promising treatment option for children with PANS/PANDAS — and one that families across the U.S. are now gaining access to through Philadelphia Integrative Psychiatry.

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What parents are seeing:

Families and early studies suggest Leucovorin may help children with PANS/PANDAS, especially those who test FRAA-positive:

  • 😌 Calmer moods, less anxiety

  • 🤏 Fewer or milder tics

  • 🔄 Reduced OCD intensity

  • 🎯 Sharper focus and organization

  • 💪 Improved energy and resilience

These aren’t miracle claims — they’re results supported by research on Leucovorin (folinic acid) treatment for PANS/PANDAS.

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Leucovorin Research Highlights

FRAA found in ~64% of children with PANS/PANDAS

Read the study ↗️

Could Folate Receptor Autoantibodies Be the Missing Link in PANS/PANDAS?

Read the blog post ↗️

Who Qualifies for Leucovorin Treatment?

Your child may be eligible if they have:

  • 🧠 A PANS or PANDAS diagnosis

  • 🧪 A positive FRAT test confirming folate receptor autoantibodies

  • 🔄 OCD, tics, or sudden neuropsychiatric symptoms

  • ✅ PLUS Live in one of our licensed-to-treat states

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How Our Leucovorin Treatment Process Works:

1. Fill out our intake form

This form gives us a chance to understand your story and what you need most. It also helps us confirm that you’re in our service area so we can provide Leucovorin treatment to you.

2. Connect with our team

Meet with Dr. Danish or a licensed team member for a 25-minute intake to see if Leucovorin, FRAT testing, or both are the right fit.

3. Choose your path

After our call, you’ll either begin a 12-week Leucovorin treatment plan, move forward with FRAT testing at a local lab, or take both steps together if that’s the best fit.

4. Stay Connected

Reach out anytime through our portal, and schedule follow-ups only when you need them.

5. Nationwide Access

FRAT testing is available in all 50 states, and Leucovorin prescriptions are offered in 40+ states—so care can reach you wherever you are.

It all starts with sharing your story through our intake form and scheduling a call with our team.

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⚠️ Important: Leucovorin addresses the nutritional/metabolic side of PANS/PANDAS. It does not replace antibiotics, antivirals, or immune treatments — but may make children more responsive to therapy and other interventions.

Leucovorin Treatment FAQ

To learn more about the Leucovorin treatment process and pricing, please refer to our FAQs :

Leucovorin FAQ

Philadelphia Integrative Psychiatry is a licensed clinical practice offering innovative, research-informed psychiatric treatments.

Leucovorin treatment for PANS/PANDAS is led by Dr. David Danish, a double board-certified child, teen, and adult psychiatrist with over 20+ years of experience. Dr. Danish and the Philly Integrative team are committed to making Leucovorin treatment safe, accessible, and supported every step of the way.

If your child struggles with PANS or PANDAS, Leucovorin could be an important piece of the recovery puzzle.

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