Could folate receptor antibodies be affecting your fertility or pregnancy?
Folate receptor antibodies (FRAs) can block folate from reaching the placenta and developing baby — even if blood folate and prenatal vitamins look normal. This hidden problem is linked to miscarriage, neural tube defects, and fertility struggles.
Philadelphia Integrative Psychiatry (Philly Integrative) offers FRAT testing nationwide to help women and families uncover this overlooked cause.
- Available in all 50 states
- Local blood draw
- Results in 6-12 weeks
⚠️ Important: Philly Integrative provides FRAT testing for fertility/pregnancy cases, but does not prescribe Leucovorin for this indication. Treatment should be managed by your OB/GYN or fertility specialist.
Why Folate Receptor Antibody Testing (FRAT) Matters in Pregnancy
Even if you’re taking good prenatal vitamins and eating well, your body might still block folate from getting to your baby if certain antibodies (called Folate Receptor Antibodies, or FRAs for short) are present.
FRAT testing helps make sure the folate is actually reaching where it’s needed most during pregnancy.
This transport problem increases risks for:
Neural tube defects
Recurrent miscarriage
Preterm birth
Subfertility or difficulty conceiving
The Solution? FRAT Testing.
The Folate Receptor Antibody Test (FRAT) is the only test that detects these antibodies.
If positive, your OB/GYN can use the results to guide treatment — which may include high-dose folinic acid (Leucovorin) or other targeted interventions.
What Research Shows
Blocking FRAs & Fertility: Women with blocking FRAs had 12x higher risk of subfertility
Neural Tube Defects: Mothers in NTD-affected pregnancies were far more likely to have blocking FRAs
Who Should Consider FRAT Testing?
Women with recurrent miscarriage or fertility struggles
Women with a family history of neural tube defects
Women with unexplained pregnancy complications
Anyone seeking reassurance before or during pregnancy
How the FRAT Testing Process Works
Getting started with FRAT testing is simple with Philadelphia Integrative Psychiatry
1. Order Your Test Kit
Delivered to your home with easy instructions.
2. Prep
Stop high-dose folate (Leucovorin or L-methylfolate) 48 hours before blood draw.
3. Complete the Draw
Bring your kit to a participating lab or phlebotomy service. They’ll collect your sample and send it to the specialized lab for testing.
4. Results in 6-12 Weeks
You’ll receive a report showing if antibodies were found.
5. Next Steps
Share results with your OB/GYN or fertility provider for treatment planning.
⚠️ Important: Philly Integrative provides FRAT testing for fertility/pregnancy cases, but does not prescribe Leucovorin for this indication. Treatment should be managed by your OB/GYN or fertility specialist.
Philadelphia Integrative Psychiatry offers innovative, research-informed psychiatric care.
For those planning a pregnancy or facing fertility challenges, FRAT testing may reveal the missing piece—helping you and your OB/GYN create the right treatment plan.