Could folate deficiency be blocking your recovery from depression?
For people with depression that doesn’t respond to medication, hidden folate transport issues in the brain may be the missing link.
Leucovorin (folinic acid) is a breakthrough prescription treatment that can bypass these blocks and restore the nutrients needed to regulate mood. Philadelphia Integrative Psychiatry is making Leucovorin treatment accessible nationwide.
- Licensed in 40+ states
- Led by double board-certified psychiatrist Dr. David Danish.
Why Leucovorin?
What looks like symptoms may actually be a blocked brain pathway.
Some people with treatment-resistant depression don’t improve, even after multiple antidepressants and therapy. One reason: A hidden folate transport problem in the brain.
Why does this matter?
Folate (B9) is critical for producing serotonin, dopamine, and mood-regulating brain chemicals
If folate receptors are blocked by antibodies, the brain can become folate-starved — a condition called cerebral folate deficiency (CFD)
Standard folic acid or even L-methylfolate may not work if the receptor is blocked.
When folate can’t reach the brain, Leucovorin helps open the door.
Leucovorin uses an alternate transport route to restore brain folate, allowing neurotransmitters to rebalance and antidepressants to work more effectively. This makes Leucovorin a promising treatment option for depression — and one that you and families across the U.S. can now gain access to through Philadelphia Integrative Psychiatry.
What patients are seeing:
Some patients with treatment-resistant depression (TRD) report improvements within weeks to months of starting Leucovorin:
🌤️ Brighter mood and reduced depression severity
💡 Clearer thinking and focus
🔋 More stable energy
🎯 Better antidepressant response
These aren’t miracle claims — they’re results supported by research on Leucovorin (folinic acid) treatment for depression.
Leucovorin Research Highlights
Low brain folate is linked to poor antidepressant response
Reviews confirm folate transport dysfunction is a driver in some cases of TRD
Who Qualifies for Leucovorin Treatment?
You may be eligible if you have:
☁️ A diagnosis of depression that has not fully improved with medications/therapy
🧪 A positive FRAA (FRAT test) or suspected folate transport issue
🧠 Symptoms such as fatigue, brain fog, or slowed cognition
✅ PLUS Live in one of our licensed-to-treat states
How Our Leucovorin Treatment Process Works:
Getting started with Leucovorin treatment for depression is simple with Philadelphia Integrative Psychiatry
1. Fill out our intake form
This form gives us a chance to understand your story and what you need most. It also helps us confirm that you’re in our service area so we can provide Leucovorin treatment to you.
2. Connect with our team
Meet with Dr. Danish or a licensed team member for a 25-minute intake to see if Leucovorin, FRAT testing, or both are the right fit.
Note: This intake is not a full autism evaluation or a comprehensive psychiatric medication review.
3. Choose your path
After our call, you’ll either begin a 12-week Leucovorin treatment plan, move forward with FRAT testing at a local lab, or take both steps together if that’s the best fit.
4. Stay Connected
Reach out anytime through our portal, and schedule follow-ups only when you need them.
5. Nationwide Access
FRAT testing is available in all 50 states, and Leucovorin prescriptions are offered in 40+ states—so care can reach you wherever you are.
It all starts with sharing your story through our intake form and scheduling a call with our team.
⚠️ Note: Leucovorin is not a replacement for standard antidepressants — but it may unlock treatment response when folate transport is the hidden barrier.
Leucovorin Treatment FAQ
To learn more about the Leucovorin treatment process and pricing, please refer to our FAQs :
Philadelphia Integrative Psychiatry is a licensed clinical practice offering innovative, research-informed psychiatric treatments, including those for depression.
Leucovorin treatment for PANS/PANDAS is led by Dr. David Danish, a double board-certified child, teen, and adult psychiatrist with over 20+ years of experience. Dr. Danish and the Philly Integrative team are committed to making Leucovorin treatment safe, accessible, and supported every step of the way.